Gonadotropin-releasing hormone (GnRH) is a hormone produced by the hypothalamus, a region of the brain. GnRH is released into the bloodstream and travels to the pituitary gland, where it stimulates the production and release of two other hormones: luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH and FSH play important roles in the regulation of the menstrual cycle in women and the production of sex hormones in both men and women.
In women, GnRH helps to regulate the menstrual cycle and the production of estrogen and progesterone. In men, GnRH helps to regulate the production of testosterone. Abnormalities in GnRH production or signaling can affect the menstrual cycle and the production of sex hormones, leading to fertility problems or other health issues.
GnRH agonists and antagonists are medications that can be used to manipulate GnRH signaling in the body. These medications are used to treat a variety of conditions, including endometriosis, uterine fibroids, and prostate cancer. They can also be used to suppress ovarian function in the treatment of infertility or to induce ovulation. If you have questions about GnRH or its role in your health, it is best to speak with a healthcare professional.« Back to Glossary Index