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Nonvalvular atrial fibrillation (NVAF) is a type of atrial fibrillation that occurs in the absence of significant valvular heart disease. In NVAF, irregular heartbeat is caused by disorganized electrical signals in the heart’s upper chambers (atria), which can lead to an increased risk of blood clots and stroke. NVAF is a common type of atrial fibrillation and is typically managed with anticoagulant medications to reduce the risk of stroke, as well as rate control and rhythm control strategies to manage symptoms and reduce the risk of complications.